Comparativeanalysisofcytomegalovirusretinitisandmicrovascularretinopathyinpatientswithacquiredimmunodeficiencysyndrome

摘要： AIM:Tocomparetheclinicalmanifestationofcytomegalovirus(CMV)retinitisandmicrovascularretinopathy(MVR)inpatientswithacquiredimmunodeficiencysyndrome(AIDS)inChina.METHODS:Atotalof93consecutivepatientswithAIDS,including41casesofCMVretinitisand52casesofMVRwereretrospectivelyreviewed.Highlyactiveantiretroviraltherapy(HAART)statuswasrecorded.HIVandCMVimmunoassaywerealsotested.CD4+T-lymphocytecountandbloodCMV-DNAtestwereperformedinallpatients.AqueoushumorCMV-DNAtestwascompletedin39patients.Ophthalmologicalexaminationsincludingbestcorrectedvisualacuity(BCVA,byInternationalStandardVisionChart),intraocularpressure(IOP),slit-lampbiomicroscopy,indirectophthalmoscopywereperformed.RESULTS:InMVRgroup,theanteriorsegmentexaminationwasnormalinallpatientswithameanBCVAof0.93±0.13.BloodCMV-DNAwas0(0,269000)and42patients(80.77%)didnotreceiveHAART.InCMVretinitisgroup,13patients(31.71%)hadanteriorsegmentabnormality.ThemeanBCVAwas0.64±0.35andbloodCMV-DNAwas3470(0,1450000).Nineteenpatients(46.34%)hadnotreceivedHAART.MVRgroupandCMVretinitisgroupthepositiveratesofaqueousCMV-DNAwere0and50%,respectively.TwopatientswithMVRprogressedtoCMVretinitisduringthefollow-upperiod.CONCLUSION:IncomparisonofCMV,patientswithMVRhaverelativelymildvisualfunctionimpairment.Carefulophthalmologicalexaminationandclosefollow-uparemandatory,especiallyforpatientswhohavesystemiccomplications,positiveCMV-DNAtestandwithoutreceivedHAART. （共6页）